Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke.
Malin JohanssonAnnie PedersenJohn W ColeCecilia LaggingArne LindgrenJane M MaguireNatalia S RostMartin SöderholmBradford B WorrallTara M StanneChristina JernPublished in: Neurology. Genetics (2021)
In this exploratory study, we found associations between genetic variants predisposing to mLOY and stroke outcome. The significant association in women suggests underlying mechanisms related to genomic instability that operate in both sexes. These findings need replication and mechanistic exploration.