Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.

Robert KleszczAnna SzymańskaVioletta Krajka-KuźniakWanda Baer-DubowskaJarosław Paluszczak

Published in: Cellular oncology (Dordrecht) (2019)

Targeting Porcupine or the CBP/β-catenin interaction seems to be an effective strategy for the inhibition of canonical Wnt signaling in HNSCC cells. Further studies are required to confirm the possible therapeutic effect of IWP-2 and PRI-724 in HNSCC.

Keyphrases

epithelial mesenchymal transition
induced apoptosis
cell proliferation
cell cycle arrest
cancer therapy
signaling pathway
oxidative stress
endoplasmic reticulum stress
case control
drug delivery