Xanthoceraside modulates NR2B-containing NMDA receptors at synapses and rescues learning-memory deficits in APP/PS1 transgenic mice.
Lin ZhuLei YangXuemei ZhaoDanyang LiuXiaoli GuoPeng LiuTianyan ChiXuefei JiLibo ZouPublished in: Psychopharmacology (2017)
The mechanism of xanthoceraside on ameliorating learning-memory deficits might be related to decrease intracellular calcium overload, increase CaMKII-GluR1 proteins, and up-regulate trafficking of pY1472-NR2B at synapse, thereby improving LTP in APP/PS1 transgenic mice.