Robust methylation-based classification of brain tumours using nanopore sequencing.
Luis P KuschelJürgen HenchStephan FrankIvana Bratic HenchElodie GirardMaud BlanluetJulien Masliah-PlanchonMartin MischJulia OnkenMarcus CzabankaDongsheng YuanSören LukassenPhilipp KarauNaveed IshaqueElisabeth G HainFrank HeppnerAhmed IdbaihNikolaus BehrChristoph HarmsDavid CapperPhilipp EuskirchenPublished in: Neuropathology and applied neurobiology (2022)
In conclusion, nanopore sequencing allows robust and rapid methylation-based classification across the full spectrum of brain tumours. Platform-specific confidence scores facilitate clinical implementation for which prospective evaluation is warranted and ongoing.