Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth.

Jing LiuShuaiyu LongHuanan WangNannan LiuChuchu ZhangLingling ZhangYingjie Zhang

Published in: Cancer cell international (2019)

NVP-BEZ235 induced AMPK/ULK1-dependent autophagy. Targeting this autophagy suppressed colon cancer growth through further promoting apoptosis, which is a potential therapeutic option for clinical patients.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
diabetic rats
end stage renal disease
signaling pathway
skeletal muscle
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
protein kinase
cancer therapy
stress induced