Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle.
Maryam AbolghasemiSoleiman MahjoubPublished in: Molecular biology reports (2021)
Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- cell cycle arrest
- adipose tissue
- high fat diet
- metabolic syndrome
- skeletal muscle
- type diabetes
- induced apoptosis
- high fat diet induced
- endoplasmic reticulum stress
- genome wide analysis
- cell death
- genome wide identification
- risk assessment
- human health
- loop mediated isothermal amplification
- glycemic control
- label free
- case report
- real time pcr