Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation.
Tom B DavidsonAlexander H LeeMelody HsuShaina SedighimJoey R OrpillaJanet TregerMax MastallSaskia RoeschCarmen RappMildred GalvezAaron Y MochizukiJoseph AntoniosAlejandro GarciaNikesh KotechaNicholas BaylessDavid NathansonAnthony C WangRichard G EversonWilliam H YongTimothy F CloughesyLinda M LiauChristel Herold-MendeRobert M PrinsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our evidence suggests that PD-1 expression in patients with glioma reflects chronically activated effector T cells that display hallmarks of memory and exhaustion depending on its anatomic location. The decreased diversity in PD-1+ T cells suggests that the PD-1-expressing population has a narrower range of cognate antigen targets compared with the PD-1 nonexpression population. This information can be used to inform how we interpret immune responses to PD-1-blocking therapies or other immunotherapies.