Differential genetic associations between dimensions of eating disorders and alcohol involvement in late adolescent twins.

Baiyu Qi Laura M Thornton Courtney E Breiner Ralf Kuja-HalkolaJessica H BakerPaul Lichtenstein Sebastian Lundström Arpana Agrawal Cynthia M Bulik Melissa A Munn-Chernoff

Published in: Alcohol, clinical & experimental research (2023)

We observed distinct patterns of genetic and environmental effects for co-occurring eating disorder dimensions and alcohol involvement in female vs. male twins, supporting sex-specific treatment strategies for late adolescents with comorbid eating disorders and alcohol use disorder. Our findings emphasize the importance of assessing family history of multiple eating disorder dimensions while treating late adolescents with problematic alcohol use, and vice versa, to improve detection and treatment.

Keyphrases

young adults
alcohol use disorder
physical activity
genome wide
alcohol consumption
copy number
mental health
gestational age
gene expression
dna methylation
risk assessment
combination therapy
climate change
smoking cessation
replacement therapy