Impact of High Serum Levels of MMP-7, MMP-9, TGF-β and PDGF Macrophage Activation Markers on Severity of COVID-19 in Obese-Diabetic Patients.
Asmaa Nasr El-DinKamal Abd El-Sattar AtaAbdelhady Ragab Abdel-GawadNahed F FahmyPublished in: Infection and drug resistance (2021)
Macrophages were mainly polarized towards the M2 phenotype in obese-diabetic COVID-19 patients with significant upregulation of the pro-fibrotic markers MMP-7, MMP-9, PDGF, and TGF-β. Thus, high levels of MMP-7 and MMP-9 are associated with ARDS in severe COVID-19 disease among obese-diabetic patients.
Keyphrases
- coronavirus disease
- sars cov
- adipose tissue
- cell migration
- type diabetes
- weight loss
- metabolic syndrome
- transforming growth factor
- obese patients
- vascular smooth muscle cells
- cell proliferation
- respiratory syndrome coronavirus
- early onset
- smooth muscle
- bariatric surgery
- epithelial mesenchymal transition
- extracorporeal membrane oxygenation
- idiopathic pulmonary fibrosis
- long non coding rna