Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells.
Jack D ChanBianca von ScheidtBijun ZengAmanda J OliverAshleigh S DaveyAesha I AliRanjeny ThomasJoseph A TrapaniPhillip K DarcyMichael H KershawRiccardo DolcettiClare Y SlaneyPublished in: Clinical & translational immunology (2020)
Our study presents Clec9A-TNE as a prospective avenue to enhance CAR T-cell efficacy for solid cancers.