Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284.
Sara AsimusRobert PalmérMuna AlbayatyHenrik ForsmanChristina LundinMarita OlssonRikard PehrsonJohn MoMuir RussellSara CarlertDavid CloseDavid KeelingPublished in: British journal of clinical pharmacology (2020)
AZD0284 was well tolerated, rapidly and dose-dependently absorbed, and reduced stimulated IL-17A release after single and multiple dosing. The results of this study support further clinical development of AZD0284.
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