Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands ( 11 C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors.

Lisheng CaiJeih-San LiowCheryl L MorseSanjay TeluRiley DaviesLester S ManlySami S ZoghbiFrederick T ChinRobert B InnisVictor W Pike

Published in: EJNMMI research (2023)

C-NR2B-Me enantiomers showed specific binding to GluN2B receptors in rat brain in vivo. High unexpected specific binding in cerebellum was not due to σ1 receptors. Additional investigation is needed to identify the source of the high specific binding.

Keyphrases

binding protein
dna binding
transcription factor
capillary electrophoresis