Network reconstruction for trans acting genetic loci using multi-omics data and prior information.

Johann S HaweAshis SahaMelanie WaldenbergerSonja KunzeSimone WahlMartina Müller-NurasyidHolger ProkischHarald GrallertChristian HerderAnnette PetersKonstantin StrauchFabian J TheisChristian GiegerJohn ChambersAlexis BattleMatthias Heinig

Published in: Genome medicine (2022)

We demonstrate that existing biological knowledge can improve the integrative analysis of networks underlying trans associations and generate novel hypotheses about regulatory mechanisms.

Keyphrases

genome wide
healthcare
electronic health record
transcription factor
single cell
network analysis
big data
dna methylation
machine learning
genome wide association
deep learning