Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition.
Claire E MartinNoah J PhippenAva Keyvani ChahiManali TilakSara L BanerjeePeihua LuLaura A NewCasey R WilliamsonMathew J PlattJeremy A SimpsonMira KrendelNicolas BissonAnne-Claude GingrasNina JonesPublished in: Journal of the American Society of Nephrology : JASN (2022)
These findings reveal distinct, yet complementary, roles for Nck proteins in regulating podocyte adhesion, controlling GBM composition, and sustaining filtration barrier integrity.