High anti-persister activity of a promising new quinolone drug candidate in eradicating uropathogenic E. coli persisters and persistent infection in mice.

Yanyan WangBing LiangZhengming SongWujun ChenHongxia NiuDongming XingYing Zhang

Published in: Journal of applied microbiology (2023)

QDF has high anti-persister activity and its drug combinations proved highly effective against biofilm bacteria in vitro and persistent UTIs in mice, which may have implications for treating rUTIs.

Keyphrases

escherichia coli
high fat diet induced
pseudomonas aeruginosa
staphylococcus aureus
biofilm formation
candida albicans
adverse drug
emergency department
metabolic syndrome
drug induced
adipose tissue
skeletal muscle