New Secondary Metabolites from Marine-Derived Fungus Talaromyces minnesotensis BTBU20220184.

Six new compounds, talamitones A and B ( 1 and 2 ), demethyltalamitone B ( 3 ), talamiisocoumaringlycosides A and B ( 4 and 5 ), and talaminaphtholglycoside ( 6 ), together with six known compounds ( 7 - 12 ), were isolated from the marine-derived fungus Talaromyces minnesotensis BTBU20220184. The new structures were characterized by using HRESIMS and NMR. This is the first report of isocoumaringlycoside derivatives from a fungus of the Talaromyces genus. Compounds 5 , 6 , and 9 showed synergistic antibacterial activity against Staphylococcus aureus .