Chromatic Selectivity of Coumarin-Caged Oligonucleotides.
Janik KaufmannFabian SinselAlexander HeckelPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2023)
A system of two coumarin-based caging groups is presented - one absorbing in the blue (400-450 nm) and the other absorbing in the green (480-550 nm) part of the visible spectrum. Together they form a pair, which allows to selectively photoactivate the one or the other in oligonucleotides. A numerical characterization defining the term "chromatic selectivity" was proposed, and it was shown how chromatically selective uncaging can literally be titrated in a kinetic reaction scheme.