Opioid tolerance and clinically recognized opioid poisoning among patients prescribed extended-release long-acting opioids.

Jessica C Young Jennifer L Lund Nabarun Dasgupta Michele Jonsson Funk

Published in: Pharmacoepidemiology and drug safety (2018)

Over one-third of patients initiating ≥90 MME ER/LA opioids did not have evidence of opioid tolerance. The 7 days following high dose ER/LA initiation may represent a high-risk period for clinically diagnosed opioid poisoning in patients who do not have prior opioid tolerance.

Keyphrases

chronic pain
pain management
high dose
end stage renal disease
ejection fraction
low dose
newly diagnosed
chronic kidney disease
breast cancer cells
peritoneal dialysis
stem cell transplantation