Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.

Xurui Jin Wanying He Yan Zhang Enying Gong Zhangming Niu John S JiYaxi LiYi Zeng Lijing L Yan

Published in: PLoS medicine (2021)

In this study, we observed that healthier lifestyle was associated with better cognitive function among the oldest old regardless of APOE genotype. Our findings may inform the cognitive outlook for those oldest old with high genetic risk of cognitive impairment.

Keyphrases

physical activity
cognitive impairment
metabolic syndrome
cognitive decline
high fat diet
cardiovascular disease
weight loss
genome wide
gene expression
type diabetes
community dwelling
copy number
adipose tissue
dna methylation
skeletal muscle