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Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsisalbispora WP1T.

Qihao WuRobert W DeeringGaiyun ZhangBixia WangXin LiJiadong SunJianwei ChenHua-Wei ZhangDavid C RowleyHong Wang
Published in: Marine drugs (2018)
Marine actinobacteria continue to be a rich source for the discovery of structurally diverse secondary metabolites. Here we present a new hydroxymate siderophore produced by Amycolatopsis albispora, a recently described species of this less explored actinomycete genus. Strain WP1T was isolated from sediments collected at -2945 m in the Indian Ocean. The new siderophore, designated albisporachelin, was isolated from iron depleted culture broths and the structure was established by 1D and 2D NMR and MS/MS experiments, and application of a modified Marfey's method. Albisporachelin is composed of one N-methylated-formylated/hydroxylated l-ornithine (N-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo-N-methylated-hydroxylated l-ornithine (cyclo-N-Me-h-l-Orn).
Keyphrases
  • ms ms
  • heavy metals
  • polycyclic aromatic hydrocarbons
  • magnetic resonance
  • small molecule
  • high resolution
  • liquid chromatography tandem mass spectrometry
  • risk assessment
  • protein kinase
  • single cell
  • genetic diversity