MicroRNA-mediated interacting circuits predict hypoxia and inhibited osteogenesis of stem cells, and dysregulated angiogenesis are involved in osteonecrosis of the femoral head.

Gour-Shenq KaoYuan-Kun TuPei-Hsun SungFeng-Sheng WangYu-Der LuChen-Ta WuRio L C LinHon-Kan YipMel S Lee

Published in: International orthopaedics (2018)

This study combined the miRNA analysis with the bioinformatics and predicts that hypoxia, inhibited osteogenesis of stem cells, and dysregulated angiogenesis might be orchestrated through the miRNA interacting circuits in the pathogenesis of ONFH.

Keyphrases

stem cells
endothelial cells
vascular endothelial growth factor
protein kinase
cell therapy
wound healing