Cholinergic PET imaging in infections and inflammation using 11C-donepezil and 18F-FEOBV.
Nis Pedersen JørgensenAage K O AlstrupFrank V MortensenKaroline KnudsenSteen JakobsenLine Bille MadsenDirk BenderPeter BreiningMikkel Steen PetersenMariane Høgsberg SchleimannFrederik Dagnæs-HansenLars C GormsenPer BorghammerPublished in: European journal of nuclear medicine and molecular imaging (2016)
The time course of cholinergic tracer accumulation in murine abscesses was considerably different from 18F-FDG, demonstrating in the 11C-donepezil and 18F-FEOBV image distinct aspects of immune modulation. Preliminary data in humans strongly suggest that 11C-donepezil can exhibit more intense accumulation than 18F-FDG at sites of chronic inflammation. Cholinergic PET imaging may therefore have potential applications for basic research into cholinergic mechanisms of immune modulation, but also clinical applications for diagnosing infections, inflammatory disorders, and cancer inflammation.