Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.
Jana IvanidzeM MackayA HoangJ M ChiK ChengCynthia AranowBruce T VolpeBetty DiamondPina C SanelliPublished in: AJNR. American journal of neuroradiology (2019)
We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
Keyphrases
- blood brain barrier
- cerebral ischemia
- endothelial cells
- contrast enhanced
- magnetic resonance imaging
- ms ms
- case control
- case report
- mass spectrometry
- cognitive impairment
- heat stress
- single cell
- magnetic resonance
- multiple sclerosis
- brain injury
- subarachnoid hemorrhage
- liquid chromatography tandem mass spectrometry
- current status
- liquid chromatography
- simultaneous determination