Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase.
Cheng-Wen HeXue-Fei CuiShao-Jie MaQin XuYan-Peng RanWei-Zhi ChenJun-Xi MuHui LiJing ZhuQingqiu GongZhiping XiePublished in: BMC biology (2021)
Our data reveal a vacuolar membrane protein degradation process with a unique dependence on vacuole-associated Atg8 downstream of ESCRTs, and we identify a specific role of Hfl1, a protein conserved from yeast to plants and animals, in membrane targeting of Atg8.
Keyphrases
- induced apoptosis
- saccharomyces cerevisiae
- transcription factor
- cell cycle arrest
- genome wide
- cancer therapy
- drug delivery
- endoplasmic reticulum stress
- machine learning
- cell wall
- big data
- bone mineral density
- signaling pathway
- binding protein
- dna methylation
- oxidative stress
- small molecule
- cell proliferation
- amino acid
- protein protein
- artificial intelligence
- deep learning