Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients with Pneumonia: A Prospective Observational Study.
Stephen P BerginRoy F ChemalySanjeet S DadwalJoshua A HillYeon Joo LeeGhady HaidarAlfred LukAlexander DrelickPeter V Chin-HongEsther BenamuFareed KhawajaDeepa NanayakkaraGenovefa A PapanicolaouCatherine Butkus SmallMonica FungMichelle A BarronThomas DavisMicah T McClainEileen K MaziarzDeng B MadutArmando D BedoyaDaniel L GilstrapJamie L ToddChristina E BarkauskasRobert BigelowJeffrey D LeimbergerEphraim L TsalikOlivia WolfMona MugharDesiree HollemonRadha DuttaguptaDaniel S LupuSivan BercoviciBradley A PerkinsTimothy A BlauwkampVance G FowlerThomas L HollandPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
Non-invasive plasma microbial cell-free DNA sequencing significantly increased diagnostic yield in immunocompromised patients with pneumonia undergoing bronchoscopy and extensive microbiologic and molecular testing.ClinicalTrials.gov Identifier: NCT04047719.