Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans.
Suresh D MuthukumaraswamyAlexander D ShawLaura E JacksonJudith HallRosalyn MoranNeeraj SaxenaPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2015)
In this paper, we found that subanesthetic doses of ketamine, similar to those used in antidepressant studies, increase anterior theta and gamma power but decrease posterior theta, delta, and alpha power, as revealed by magnetoencephalographic recordings. Dynamic causal modeling of frontoparietal connectivity changes with ketamine indicated a decrease in NMDA and AMPA-mediated frontal-to-parietal connectivity. AMPA-mediated connectivity changes were sustained for up to 50 min after ketamine infusion had ceased, by which time perceptual distortions were absent. The results also indicated a decrease in gain of parietal pyramidal cells, which was correlated with participants' self-reports of blissful state. The alterations in frontoparietal connectivity patterns we observe here may be important in generating the antidepressant response to ketamine.
Keyphrases
- resting state
- working memory
- functional connectivity
- white matter
- pain management
- major depressive disorder
- induced apoptosis
- transcranial magnetic stimulation
- low dose
- multiple sclerosis
- emergency department
- cell cycle arrest
- cell death
- cell proliferation
- endoplasmic reticulum stress
- electronic health record
- prefrontal cortex