A novel bee-friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D-QSAR study of insect kinin analogs at Phe 2 modification.

Yuan-Lin ZhouXin-Lu LiYi-Meng ZhangYan ShiHong-Hong LiZhe ZhangChandni IqbalDe-Xing YeXue-Sheng LiYing-Ru ZhaoWei-Long XuGuy Smagghe Xin-Ling Yang

Published in: Pest management science (2022)

has a high toxicity for aphids, while a low toxicity to bees, and therefore can be considered as a lead compound to develop new biosafe aphid control agents. Finally, we provide a useful 3D-QSAR model as theoretical guidance for further structural optimization. © 2022 Society of Chemical Industry.

Keyphrases

molecular docking
molecular dynamics
oxidative stress
aedes aegypti
structure activity relationship