Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis.

Zhao LiuXilin XuYiwei ShenYuanyuan HaoWenwen CuiWenyan LiXin ZhangHang LvXiaodong LiYun-Long HouXiaofeng Zhang

Published in: Cell proliferation (2022)

This study demonstrated that ethanol consumption led to osteoporosis and intestinal-specific dysbacteriosis. Conjoint analysis of the genetic profiles of GM and metabolic phenotypes in serum and faeces allowed us to understand the endogenous metabolite, 5-HT, as detrimental regulators in the gut-bone axis to impair bone formation.

Keyphrases

bone mineral density
postmenopausal women
body composition
soft tissue
ms ms
bone loss
diabetic rats
transcription factor
genome wide
bone regeneration
gene expression
drug induced