Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages.
Luciana C VeirasEllen A BernsteinDuoYao CaoDerick Okwan-DuoduZakir KhanDavid R GibbArantxa RoachRachel N SkeltonRyan M WilliamsKenneth E BernsteinJorge F GianiPublished in: Circulation research (2022)
Renal tubular epithelial cell-derived IL-1β polarizes renal macrophages towards a proinflammatory phenotype that promotes salt sensitivity through the accumulation of renal IL-6. When tubular IL-1β synthesis is suppressed or in db/db mice in which immune cells lack the IL-1R1, macrophage polarization is blunted resulting in no salt-sensitive hypertension.