Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin amyloidosis.
Andreas ThimmAlexander CarpinteiroSara OubariMaria PapathanasiouLukas KesslerChristoph RischplerRayaz Ahmed MalikKen HerrmannHans Christian ReinhardtTienush RassafChristoph KleinschnitzTim HagenackerMark StettnerPublished in: Journal of neurology (2023)
CCM identifies small nerve fibre damage in presymptomatic carriers and symptomatic patients with ATTRv amyloidosis and may serve as a predictive surrogate marker to identify individuals at risk of developing symptomatic amyloidosis. Furthermore, increased corneal cell infiltration suggests an immune-mediated mechanism in the pathogenesis of amyloid neuropathy.
Keyphrases
- optical coherence tomography
- multiple myeloma
- wound healing
- induced apoptosis
- genome wide
- cataract surgery
- oxidative stress
- cell cycle arrest
- single cell
- peripheral nerve
- stem cells
- cell death
- mesenchymal stem cells
- dna methylation
- signaling pathway
- endoplasmic reticulum stress
- bone marrow
- cell proliferation
- wild type