New cellular imaging-based method to distinguish SPG4 subtype of Hereditary Spastic Paraplegia.
Francesca SardinaDavide ValenteGaia FattoriniEttore CioffiGianmarco Dalla ZannaAlessandra TessaDaniela TrisciuoglioSilvia SodduFilippo M SantorelliCarlo CasaliCinzia RinaldoPublished in: European journal of neurology (2023)
These findings open the possibility of a rapid, non-invasive, inexpensive test useful to recognize SPG4-hereditary spastic paraplegia subtype and evaluate the effects of spastin-enhancing drug in non-neuronal cells.
Keyphrases
- cerebral palsy
- induced apoptosis
- botulinum toxin
- cell cycle arrest
- high resolution
- upper limb
- minimally invasive
- emergency department
- cell death
- signaling pathway
- endoplasmic reticulum stress
- cerebral ischemia
- mass spectrometry
- fluorescence imaging
- loop mediated isothermal amplification
- subarachnoid hemorrhage
- cell proliferation