Soluble ACE2 Is Filtered into the Urine.
Jonathan W NelsonDavid I Ortiz-MeloNatalie K MattocksJacqueline M EmathingerJessica PrescottKatherine XuRobert C GriffithsRumie WakasakiPaul D PiehowskiMichael P HutchensThomas M CoffmanSusan B GurleyPublished in: Kidney360 (2022)
Our findings suggest that both systemic and renal tissues may contribute to sACE2 in urine, identifying the kidney as a major site for ACE2 actions. Moreover, filtration of sACE2 into the lumen of the nephron may contribute to the pathophysiology of kidney diseases characterized by disruption of the glomerular filtration barrier.