Use of fusion transcription factors to reprogram cellulase transcription and enable efficient cellulase production in Trichoderma reesei.

A new strategy based on fTFs was successfully established in T. reesei to improve cellulase titers without impairing fungal growth. This study will be valuable for lignocellulosic biorefining and for guiding the development of engineering strategies for producing other important biochemical compounds in fungal species.