Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals.
Karim NarakiRamin RezaeeHabibeh Mashayekhi-SardooA Wallace HayesGholamreza KarimiPublished in: Phytotherapy research : PTR (2020)
Mangiferin (MGF) is a polyphenolic C-glucosyl-xanthone extracted from the mango tree (Mangifera indica). MGF has shown diverse effects such as antioxidant, antiapoptotic, radical scavenging, and chelating properties. MGF also has been shown to modulate inflammatory pathways. In this review, we examined and evaluated the literature dealing with the protective effects of MGF against various chemical toxicities. Our literature review indicated that the MGF-induced protective effects against the toxic effects of pharmaceuticals, heavy metals and environmental chemicals were mainly mediated via suppression of lipid peroxidation, oxidative stress (along with enhancement of the antioxidant enzyme), inflammatory factors (TNF-α, IL-6, IL-10, and IL-12), and activation of PI3K/Akt and the MAPK survival signaling pathway.
Keyphrases
- oxidative stress
- pi k akt
- signaling pathway
- heavy metals
- diabetic rats
- induced apoptosis
- cell cycle arrest
- cell proliferation
- risk assessment
- dna damage
- ischemia reperfusion injury
- epithelial mesenchymal transition
- health risk assessment
- health risk
- human health
- anti inflammatory
- systematic review
- case report
- sewage sludge
- heat shock
- free survival