Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced Osteomalacia.

By combining laboratory diagnostics, namely, ALP and Tt.BMDRadius measured by HR-pQCT, we achieved the calculation of the virtual osteoid volume to bone volume ratio (OV/BVmodel) with a significant correlation to histology as well as reliable identification of TIO patients compared to OPO and control. This novel approach is potentially helpful for predicting osteoid volume by noninvasive techniques in diagnostic procedures and improving the clinical management of TIO.