Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.
Dawn M DudleyKoen K Van RompayLark L CoffeyAmir ArdeshirRebekah I KeeslerEliza Bliss-MoreauPeta L GrigsbyRosemary J SteinbachAlec J HirschRhonda P MacAllisterHeidi L PecoraroLois M ColginTravis HodgeDaniel N StreblowSuzette TardifJean L PattersonManasi TamhankarMaxim SeferovicKjersti M AagaardClaudia Sánchez-San MartínCharles Y ChiuAntonito T PanganibanRonald S VeazeyXiaolei WangNicholas J ManessMargaret H GilbertRudolf P BohmKristina M Adams WaldorfMichael GaleLakshmi RajagopalCharlotte E HotchkissEmma L MohrSaverio V CapuanoHeather A SimmonsAndres MejiaThomas C FriedrichThaddeus G GolosDavid H O'ConnorPublished in: Nature medicine (2018)
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.