Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.

Yaoyu PuQiuhong WuQiuping ZhangTianwen HuangJi WenLong WeiKenji HashimotoYi Liu

Published in: Psychopharmacology (2023)

These data suggest that MSC-MVs could ameliorate MPTP-induced neurotoxicity in the brain and colon via the gut-microbiota-brain axis. Therefore, MSC-MVs would have a new therapeutic potential for neurological disorders such as PD.

Keyphrases

resting state
white matter
high glucose
cerebral ischemia
diabetic rats
functional connectivity
mesenchymal stem cells
drug induced
bone marrow
stem cells
type diabetes
endothelial cells
metabolic syndrome
big data
machine learning
high fat diet induced
deep learning
skeletal muscle
cell therapy