The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts.
Karen Y ChengElsa S StrotmeyerDeborah M KadoJohn T SchousboeSimon SchenkMichael NevittNancy E LaneJan M Hughes-AustinPublished in: ACR open rheumatology (2023)
In women, but not in men, MetS was associated with hip OA. In men, but not in women, obesity was associated with hip OA. These findings suggest that mechanical effects of obesity may predominate in the pathogenesis of hip OA in men, whereas metabolic effects predominate in women.
Keyphrases
- metabolic syndrome
- insulin resistance
- polycystic ovary syndrome
- weight loss
- type diabetes
- knee osteoarthritis
- middle aged
- total hip arthroplasty
- weight gain
- high fat diet induced
- pregnancy outcomes
- bone mineral density
- uric acid
- cardiovascular disease
- breast cancer risk
- adipose tissue
- physical activity
- body mass index