Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.
Shuang ZhouZhe WangZhiyan LiuGuangyan MuQiufen XieZining WangQian XiangYanjun GongYi Min CuiPublished in: Cardiovascular drugs and therapy (2021)
The genetic polymorphisms of rs7830 (NOS3), rs62275874 (AGTR1), linkage rs471683 and rs7785386 (GNAI1|GNAT3), rs1715389 (GNAI1|GNAT3), and rs7313458 (ITPR2) may lead to an increased risk of in-stent restenosis and revascularization after the first PCI in Chinese patients by affecting the efficacy of clopidogrel. The above six SNP may be used as potential genetic biomarkers for high risk of in-stent restenosis and revascularization after the first PCI in Chinese patients.
Keyphrases
- percutaneous coronary intervention
- acute coronary syndrome
- coronary artery bypass grafting
- coronary artery disease
- genome wide
- antiplatelet therapy
- acute myocardial infarction
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- atrial fibrillation
- heart failure
- nitric oxide synthase
- nitric oxide
- hepatitis c virus
- risk assessment
- cell migration
- human health
- genetic diversity