Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms.

Jacques A J MalherbeKathryn A FullerAyesha ArshadJyoti NangaliaGiuliana RomeoSara L HallKatie L MeehanBelinda GuoRebecca HowmanWendy N Erber

Published in: Journal of clinical pathology (2015)

Uncontrolled megakaryocytic expansion in MPN results from a combination of increased proliferation, attenuated apoptosis and defective epigenetic regulation with CALR mutations favouring apoptotic failure. The higher platelet counts reported to be seen in MPN with CALR mutations may be due to greater dysregulation of megakaryocyte apoptosis.

Keyphrases

cell death
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
anti inflammatory
dna methylation
gene expression
signaling pathway
cell proliferation
pi k akt