Orexin a levels of adolescents with major depressive disorder.

Adolescent MDD is not associated with orexin A according to the findings of this study. Future studies considering the effect of stress on this relationship would improve our understanding of this issue.Key PointsAdult studies exploring the relationship between orexin A and major depressive disorder reported contradictory findings.This study showed no relationship between serum orexin A levels and depressive symptom severity among adolescents with major depressive disorder.Orexin A levels of the subjects with major depressive disorder are not significantly different from healthy adolescents.