Country wide surveillance reveals prevalent artemisinin partial resistance mutations with evidence for multiple origins and expansion of sulfadoxine-pyrimethamine resistance mutations in northwest Tanzania.

561H resistant mutation is entrenched in the region and that multiple origins of ArtR, similar as to what was seen in Southeast Asia, are likely to occur. Mutations associated with high levels of SP resistance are increasing. These results raise concerns about the long-term efficacy of artemisinin and chemoprevention antimalarials in the region.