Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation.
Marta Ciszek-LendaMagdalena StrusMaria WalczewskaGrzegorz MajkaAgnieszka Machul-ŻwirblaDiana MikołajczykSabina GórskaAndrzej GamianBenjamin ChainJanusz MarcinkiewiczPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
Phagocytes exposed to biofilm microenvironment, called by us biofilm-associated neutrophils/macrophages (BANs/BAMs), display secretory properties similar to that of N1/M1-type phagocytes. These results suggest that in vivo high concentrations of LPS and DNA, trapped in biofilm by EPS, might convert infiltrating phagocytes into cells responsible for tissue injury without direct contact with bacteria and phagocytosis.