Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31 P-CMRS in the mouse.

Mahon L MaguireDebra J McAndrewHannah A LakePhilip J OstrowskiSevasti ZervouStefan NeubauerCraig A LygateJurgen E Schneider

Published in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2023)

P-CMRS methodology for the in vivo assessment of energetics in the murine heart which enabled high-resolution imaging within acceptable scan times. Mice over-expressing both creatine and CK in the heart exhibited a synergistic elevation in PCr/ATP that can now be tested for therapeutic potential in models of chronic heart failure.

Keyphrases

high resolution
heart failure
protein kinase
mass spectrometry
atrial fibrillation
computed tomography
left ventricular
high speed
high fat diet induced
tandem mass spectrometry
ejection fraction
cancer therapy
wild type
type diabetes
magnetic resonance imaging
adipose tissue
clinical evaluation