Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes.

James R SmithBeatrice S L CollinsMatthew J HesseMark A GrahamEddie L Myers Varinder Kumar Aggarwal

Published in: Journal of the American Chemical Society (2017)

We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp2-sp3 hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

Keyphrases

room temperature
electron transfer