Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns.
E E ChristensenMarthe Jøntvedt JørgensenKristin G NoreT B DahlK YangT RanheimC HuseA LindS NurB StiksrudSynne JenumKristian TonbyJ C HolterAleksander Rygh HoltenBente HalvorsenAnne Margarita Dyrhol-RiisePublished in: Journal of internal medicine (2021)
Critical COVID-19 seems to be characterized by an immune profile of activated and exhausted T cells and monocytes. This immune phenotype may influence the capacity to mount an efficient T-cell immune response. Plasma B-cell activity and calprotectin were higher in critical COVID-19 while most transcripts related to immune functions were reduced, in particular affecting B cells. The potential of these cells as therapeutic targets in COVID-19 should be further explored.