Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.

Nicolas PerrotSébastien ThériaultSidwell RigadeHao Yu ChenChristian DinaAndreas MartinssonS Matthijs BoekholdtRomain CapouladeThierry Le TourneauDavid Messika-ZeitounJames C EngertNicholas J WarehamMarie-Annick ClavelPhillippe PibarotJ Gustav SmithJean Jacques SchottPatrick MathieuYohan BosséGeorge ThanassoulisBenoit J Arsenault

Published in: Heart (British Cardiac Society) (2020)

Higher Lp-PLA2 activity is significantly associated with the presence of CAVS and might represent a biomarker of CAVS in patients with heart disease. Results of our genetic association study suggest that Lp-PLA2 is however unlikely to represent a causal risk factor or therapeutic target for CAVS.

Keyphrases

aortic valve
transcatheter aortic valve replacement
transcatheter aortic valve implantation
aortic valve replacement
aortic stenosis
risk factors
genome wide
pulmonary hypertension
gene expression
copy number
coronary artery disease
dna methylation