Prediction of thiopurine failure in pediatric Crohn's disease: pediatric IBD Porto group of ESPGHAN.

Tereza LerchovaOndrej HradskyMichal KulichGabor VeresJorge Amil DiasMałgorzata SładekSanja KolacekStephanie Van BiervlietJan MelekDaniela E SerbanKatrine WintherTim de MeijJan SchwarzKaija-Leena KolhoJohanna C EscherJiri Bronsky

Published in: Pediatric research (2022)

The possibility of predicting relapse on AZA treatment appears to be possible but limited. We identified six independent predictors available at diagnosis of early AZA/6-MP treatment failure in pediatric CD patients. Using combination of these factors, a model applicable to clinical practice was created. A web-based tool, allowing estimation of individual relapse risk in pediatric CD patients on a particular therapeutic regimen, has been developed.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
clinical practice
prognostic factors
peritoneal dialysis
young adults
patient reported outcomes