Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.

Bin Gu John R ShorterLucy H WilliamsTimothy A BellPablo HockKatherine A DaltonYiyun PanDarla R MillerGinger D ShawBenjamin D Philpot Fernando Pardo-Manuel de Villena

Published in: Epilepsia (2020)

New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics. We performed a phenotypic screen utilizing a novel genetic reference population of CC mice. The data we provide enable the identification of protective/risk genes and novel molecular mechanisms linked to complex seizure traits that are currently challenging to study and treat.

Keyphrases

genome wide
dna methylation
temporal lobe epilepsy
copy number
high fat diet induced
mouse model
small molecule
climate change
metabolic syndrome
bioinformatics analysis
electronic health record
big data
quality improvement
artificial intelligence
insulin resistance
wild type
data analysis
deep learning