In Vitro Anticancer Effects of All-trans Retinoic Acid in Combination with Dacarbazine against CD117+ Melanoma Cells.

Bahareh Mohammadi JobaniElham MohebiNajafzadeh Nowruz

Published in: Drug research (2020)

Collectively, combined treatment with ATRA and dacarbazine induced more apoptosis and enhanced the cell cycle arrest of CD117+ melanoma cells. These results suggested that ATRA increased the sensitivity of melanoma cells to the effect of dacarbazine.

Keyphrases

cell cycle arrest
cell death
pi k akt
nk cells
diabetic rats
oxidative stress
signaling pathway
endoplasmic reticulum stress
cell proliferation
combination therapy
smoking cessation